№ files_lp_4_process_3_110057
File format: docx Character count: 18230 File size: 5668 KB
Comprehensive review of experimental methods for chemoselective ligation and bioconjugation of peptides and macromolecules, summarizing reaction types, mechanisms, applications, and chemical modifications for the synthesis and labeling of biomolecules.
Year: 1994–2014
Region / Institution: International / Various research institutions
Subject: Peptide synthesis, chemoselective ligation, bioconjugation
Document type: Scientific review / research summary
Authors: Kent, Bertozzi, Bode, Dawson, Danishefsky, Hilvert, Tam, Lau, Macmillan
Target audience: Researchers in chemistry and biochemistry
Key techniques: Native Chemical Ligation (NCL), KAHA Ligation, Selenocysteine ligation, Homocysteine ligation, KAT Ligation, auxiliary-mediated ligation
Molecule size range: Peptides up to ~200 amino acids, small proteins
Publication references: Bertozzi Trends Biotech. 1998, Kent Science 1994, Kent JACS 1997, Danishefsky Science 2013, Bode ACIE 2006–2014
Chemical modifications: Cys to Ala conversion, incorporation of auxiliary groups, oxaproline-mediated ligation
Solvent / conditions: Aqueous buffers, mild conditions, low to moderate concentrations
Reaction criteria: Chemoselectivity, covalent bond formation, stability of reactants, non-toxicity, reasonable reaction rate
Price: 8 / 10 USD
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Efficacy and Safety of Transjugular Intrahepatic Portosystemic Shunt Compared to Endoscopic Variceal Ligation for Variceal Rebleeding Prevention: A Systematic Review and Meta-Analysis
Year: 2026
Region / City: International, primarily Egypt and Yemen
Topic: Gastroenterology, Hepatology
Document Type: Systematic Review and Meta-Analysis
Authors: Abdelaziz A. Awad, Alaa Ramadan, Abdelrahman M. Elettreby, Yousef Radwan Hussein, Ahmed Zabady, Esraa Abdelhafz, Youssef Elamin, Mahmoud Ali, Merna R. Roshdy, Omar Abdelrahim, Moustafa S. Mohamed, Mohamed Elmasry, Naji al-bawah, Mohamed Fakhry
Target Audience: Medical researchers, clinicians in hepatology and gastroenterology
Study Period: Not specified
Databases Reviewed: PubMed, WOS, SCOPUS, EMBASE
Keywords: TIPS, Endoscopic Variceal Ligation, Variceal Rebleeding, Gastrointestinal Bleeding, Safety, Hepatic Encephalopathy, Mortality, Prophylaxis
Methodology: Meta-analysis, systematic review, trial sequential analysis, meta-regression, sensitivity analysis
Figures Included: 40, including forest plots, leave-one-out sensitivity analyses, funnel plots, Galbraith plots
Context: Peer-reviewed research article analyzing multiple studies to compare the outcomes of TIPS versus endoscopic variceal ligation for preventing variceal rebleeding, assessing safety, complications, and mortality.
Topics: Bioconjugation Ligation Macromolecules