№ files_lp_4_process_3_071169
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Study report describing the effect of Nox1 deficiency on Salmonella Typhimurium-induced typhlitis in mice, including infection outcomes, histological assessment, and gene expression analysis in cecal tissue.
Year: 2016
Journal: World Journal of Gastroenterology
Manuscript Type: Original Article, Basic Study
Authors: Fong-Fong Chu, R Steven Esworthy, James H Doroshow, Binghui Shen
Affiliations: Department of Gastroenterology and Hepatology, The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China; Department of Cancer Genetics and Epigenetics, Beckman Research Institute of City of Hope, Duarte, CA, United States; Center for Cancer Research and Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD, United States
Funding: National Cancer Institute, NIH
Open Access: Yes, Creative Commons Attribution Non Commercial (CC BY-NC 4.0)
Correspondence: Fong-Fong Chu, [email protected]
Study Model: Male wild-type and Nox1 knockout C57BL6/J mice, 8 weeks old
Experimental Method: Oral Salmonella Typhimurium infection following metronidazole treatment
Observation Period: 4 days post-inoculation
Ethics Approval: Protocol 11043, City of Hope BRI Institutional Animal Care and Use Committee, 2012, renewed 2014
Conflict of Interest: None declared
Keywords: NADPH oxidase-1, Salmonella Typhimurium, typhlitis, knockout mouse, reactive oxygen species
Publication Status: In press, published online
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