№ lp_2_3_30111
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Scientific research article presenting a proteomic investigation of protein haptenation by diphenylcyclopropenone and ethyl acrylate in human serum albumin and HaCaT keratinocyte lysates within the context of skin sensitisation and allergic contact dermatitis.
Authors: Erika Parkinson; Maja Aleksic; Rachael Arthur; Sergio Regufe Da Mota; Richard Cubberley; Paul J. Skipp
Corresponding author: Paul Skipp, Ph.D.
Affiliations: Biological Sciences, University of Southampton; Centre for Proteomic Research, Institute for Life Sciences, University of Southampton; Safety & Environmental Assurance Centre, Unilever, Colworth Science Park
Region: Southampton, UK; Sharnbrook, UK
Thematic area: Proteomics; Skin sensitisation; Allergic contact dermatitis; Chemical toxicology
Keywords: allergic contact dermatitis; Diphencyprone; Ethyl Acrylate; HSA; MSE; proteomics; sensitization; skin
Abbreviations: Diphenylcyclopropenone (DPCP); Diphencyprone; Ethyl Acrylate (EA); Human Serum Albumin (HSA); HaCaT
Type of document: Scientific research article
Subject of study: Protein haptenation in HSA and HaCaT cell lysates induced by DPCP and EA
Methodology: Stable isotope labelling combined with data-independent acquisition mass spectrometry (HDMSE/DIA)
Institutional context: Academic and industry collaboration
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