№ files_lp_4_process_2_73139
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Medical case series describing perioperative desensitization protocols enabling safe administration of protamine for heparin reversal during cardiopulmonary bypass in two patients with confirmed IgE-mediated protamine hypersensitivity undergoing complex cardiac surgery.
Year: Not specified
Country: France
City / Region: Lyon; Clermont-Ferrand; Créteil
Field: Cardiac surgery; anesthesiology; immunology
Document Type: Medical case series article
Medical Topic: IgE-mediated protamine hypersensitivity during cardiopulmonary bypass
Keywords: anaphylactic shock; cardiac surgery; cardiopulmonary bypass; protamine; heart transplantation; IgE-mediated hypersensitivity; immunologic desensitization
Authors: Philippe Portran; Martin Charvin; Matthias Jacquet-Lagreze; Léa Didier; Matteo Pozzi; Laurent Sebbag; Benoit Bensaid; Jean-Luc Fellahi
Affiliated Institutions: Hôpital Louis Pradel, Hospices Civils de Lyon; Centre hospitalo-universitaire Clermont-Ferrand; Université Claude Bernard Lyon 1; Inserm UMR 1060; Edouard Herriot Hospital; French National Reference Center for Toxic Bullous Dermatoses
Corresponding Author: Philippe Portran
Corresponding Author Email: [email protected]
Patient Population: Adult patients with confirmed IgE-mediated protamine allergy requiring cardiac surgery
Clinical Context: Cardiac surgery with cardiopulmonary bypass requiring heparin reversal with protamine
Intervention: Perioperative immunologic desensitization protocol to protamine
Number of Cases: Two
Word Count: 1350
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