№ files_lp_4_process_1_48001
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Peer-reviewed biomedical research article examining transcriptomic changes and signaling regulation in human fibroblast reprogramming induced by fish oocyte extracts with emphasis on SMAD6-mediated modulation of the TGF-β/BMP pathway.
Document type: Scientific research article
Research field: Stem cell biology and regenerative medicine
Main topic: Molecular mechanisms of somatic cell reprogramming
Key molecule: SMAD6
Signaling pathway: TGF-β/BMP signaling pathway
Biological process: Oocyte extract–induced cellular reprogramming
Cells studied: Human skin fibroblasts (HSFs)
Induced cell type: Induced multipotent stem cells (IMS)
Key pluripotency markers: OCT4, NANOG
Experimental approach: Transcriptomic analysis and functional validation
Materials used: Fish oocyte extract, human skin fibroblasts
Cell culture conditions: DMEM/F12 medium with 10% fetal bovine serum, 37°C, 5% CO₂
Author: Wei-Wen Fan; He-Ling Yuan; Ying Zhang; Xi-Long Zhao; Qiang Wang; Xue-Feng Bai; Xing-Hua Pan; Xiang-Qing Zhu
Author contribution note: Wei-Wen Fan, He-Ling Yuan, and Ying Zhang contributed equally
Correspondence: Xiang-Qing Zhu; Xing-Hua Pan
Institution: The Basic Medical Laboratory of the 920th Hospital of Joint Logistics Support Force of PLA
Laboratories: The Transfer Medicine Key Laboratory of Cell Therapy Technology of Yunnan Province; The Integrated Engineering Research Center of Cell Biological Medicine of State and Regions
City: Kunming
Province: Yunnan Province
Country: China
Research objective: Investigation of gene expression dynamics and signaling regulation during fish oocyte extract–induced reprogramming of human somatic cells
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