№ files_lp_4_process_1_47949
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This narrative review synthesizes epidemiological, mechanistic, and regulatory evidence to evaluate the potential link between prenatal acetaminophen use and autism spectrum disorder (ASD), offering guidance for clinical practice and policy formulation.
Year:
2025
Region / City:
United States
Topic:
Prenatal Health, Neurodevelopmental Disorders, Medication Safety
Document Type:
Narrative Review
Institution:
U.S. Department of Health and Human Services, U.S. Food and Drug Administration
Author:
Not specified
Target Audience:
Healthcare Providers, Researchers, Pregnant Individuals
Effective Period:
Ongoing
Approval Date:
September 2025
Modification Date:
September 2025
Price: 8 / 10 USD
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The product description is provided for reference. Actual content and formatting may differ slightly.
Year:
N/A
Region / city:
N/A
Topic:
miR-122, hepatocyte cultures, acetaminophen, diclofenac, cytotoxicity
Document type:
Supplementary figure
Author:
N/A
Target audience:
Researchers in the field of hepatology, toxicology, and molecular biology
Period of validity:
N/A
Date of approval:
N/A
Date of amendments:
N/A
Year:
Not specified
Document Type:
Supplementary information
Subject:
Quantitative analysis of acetaminophen and metabolites in plasma
Analytes:
APAP, APAP-G, APAP-S, APAP-C, APAP-NAC, APAP-SG
Biological Matrices:
Rat plasma; pig plasma; human plasma
Analytical Method:
U(H)PLC-MS
Institutions:
Imperial College London; GlaxoSmithKline R&D; AstraZeneca; Royal Veterinary College; UCL Institute for Liver and Digestive Health
Geographical Location:
London; Ware; Cambridge; Hertfordshire, United Kingdom
Content Elements:
Calibration curve preparation; quality control samples; stock solution preparation; internal standard preparation; validation data
Validation Scope:
Rat plasma method validation over three days
Tables Included:
S1–S8
Year:
2025-2026
Region / City:
South Carolina
Topic:
Legislation, Prenatal Rights
Document Type:
Bill
Body:
South Carolina General Assembly
Author:
Reps. Harris, Magnuson, Chumley, Burns, Long, Beach, Huff, Rankin, Sanders, Frank, Lastinger
Target Audience:
Legislators, Legal Professionals, General Public
Period of Effect:
2025-2026
Approval Date:
TBD
Date of Changes:
TBD
Year:
2025-2026
Region / City:
Hawaii
Theme:
Health, Early Childhood, Maternal and Infant Health
Document Type:
Evaluation Report
Organ / Institution:
Hawaii Department of Health, Family Health Services Division
Author:
Not specified
Target Audience:
Community leaders, non-profit organizations, state departments, medical office providers, health centers, doulas, midwives, mental health consultants, policy advocates, family leadership developers
Period of Implementation:
10/27/25 to 7/29/26
Approval Date:
Not specified
Date of Changes:
Not specified
Note:
Year
SNP Array Platform:
Whole Genome Infinium CytoSNP-850K v1.2 Illumina BeadChip array.
Analysis Software:
BlueFuse Multi v4.4
Genome Build:
GRCh37
Average Backbone Resolution:
approximately 50kb
Average Targeted Gene Resolution:
approximately 10kb
Incidental Findings:
Yes
Sample Type:
Amniotic Fluid, CVS, Parental Blood
Interpretation of Results:
Yes
Testing Limitations:
Yes
Contact Information:
Yes
Year:
2023
Region / City:
Singapore
Field:
Child and Maternal Health
Document Type:
Proposal
Institution:
A*STAR
Author:
Not specified
Target Audience:
Researchers, Institutions, Funders
Period of Effect:
Not specified
Approval Date:
Not specified
Date of Changes:
July 2023
Year:
2021
Region / City:
Wisconsin
Topic:
Postpartum Care, Prenatal Care Coordination
Document Type:
Assessment Tool
Institution:
Department of Health Services, Division of Public Health
Target Audience:
Healthcare Providers, Prenatal Care Providers
Period of Validity:
Not specified
Approval Date:
Not specified
Revision Date:
Not specified
Year:
2023
Region / City:
North Carolina
Subject:
Prenatal SSRIs, Infant Development, Negative Affect
Document Type:
Research Paper
Organization:
University of North Carolina at Chapel Hill
Author:
Gabrielle Adams
Target Audience:
Researchers, Medical Professionals
Period of Validity:
N/A
Approval Date:
N/A
Date of Changes:
N/A
Year:
2023
Region / City:
Connecticut
Topic:
Prenatal Substance Exposure, Child Welfare, Family Care Plans
Document Type:
Policy Guidelines
Agency / Institution:
Department of Children and Families (DCF), Connecticut
Author:
Connecticut State Government
Target Audience:
Healthcare Providers, Child Welfare Professionals
Effective Period:
Ongoing
Approval Date:
Not specified
Revision Date:
Not specified
Date of Notification:
2023
Note:
Year
Topic:
Prenatal Exercise, Maternal Health
Document Type:
Study Report
Year:
2025
Organization:
Alder Hey Children’s NHS Foundation Trust
Department:
Department of Respiratory Medicine
Document type:
Patient information leaflet
Target audience:
Patients, parents and carers of children with cystic fibrosis
Topic:
Genetics of cystic fibrosis, carrier testing, reproductive options
Review date:
March 2025
Contact:
Tel: 0151 228 4811, www.alderhey.nhs.uk
Location:
Liverpool, United Kingdom
Field:
Fetal cardiology
Topic:
Prenatal prediction of hypoplastic left heart syndrome (HLHS)
Document type:
Figure captions
Imaging modality:
Ultrasound (four-chamber view)
Analytical approach:
Multimodal nomogram
Machine learning models:
Decision Tree (DT), Random Forest (RF), Support Vector Machine (SVM), XGBoost
Neural network architecture:
Residual Variational Autoencoder (RVAE)
Data types:
Demographic characteristics; morphological cardiac characteristics; ultrasound image features
Key anatomical structures:
Left atrium (LA); right atrium (RA); left ventricle (LV); right ventricle (RV)
Evaluation methods:
ROC curve analysis; Decision Curve Analysis (DCA); cross-correlation analysis
Visualization methods:
Grad-CAM heatmaps; box plots; workflow diagrams
Study population:
Fetuses undergoing prenatal ultrasound examination
Example gestational ages:
25 weeks gestation; 27 weeks gestation
Clinical focus:
Prenatal risk assessment of hypoplastic left heart syndrome
Year:
2018
Region:
United States
Topic:
Prenatal substance exposure, neonatal health, early childhood education
Document type:
Educational resource kit
Organization:
Zero to Three, KCCTO-KITS, U.S. Department of Health & Human Services
Author:
Multiple contributors, including Child Welfare Information Gateway, CDC, Forray, Greer, Patrick et al.
Target audience:
Early care and education providers, childcare professionals, healthcare workers
Period covered:
2000–2018
Date published:
2018
References:
CDC (2018), Zero to Three (2012, 2018), Patrick et al. (2015), Kim & Stabler (n.d.), Greer (2017), Forray (2016), Kozhimannil et al. (2017), Child Welfare Information Gateway (2014)
Format:
Virtual kit with PDFs, guides, videos, and training links
Context description:
Comprehensive educational source detailing the prevalence, symptoms, and care considerations for infants prenatally exposed to legal and illegal substances, including guidance for early childhood providers on interventions and family support.
Year:
2023
Region / City:
Wisconsin
Subject:
Prenatal Care Coordination
Document Type:
Form
Organization:
Department of Health Services, State of Wisconsin
Author:
Not specified
Target Audience:
Medicaid Providers
Period of Validity:
Ongoing
Approval Date:
Not specified
Modification Date:
Not specified
Year:
2021
Event:
Expert meeting
Location:
Online
Organization:
UNESCO
Topic:
Intangible cultural heritage, listing mechanisms
Type of document:
Report / Meeting overview
Author:
Rieks Smeets
Target audience:
UNESCO member states, cultural heritage experts
Dates of event:
26–27 May 2021
Time:
13:00–16:00 (Paris time / UTC+2)
Historical period covered:
1960s–2008
Year:
2021
Region / city:
Online
Subject:
Intangible Cultural Heritage
Document type:
Background Paper
Organization:
UNESCO
Author:
UNESCO Secretariat
Target audience:
Experts, States Parties, practitioners in the field of intangible cultural heritage
Duration:
May 2021 – ongoing
Approval date:
Not provided
Amendment date:
Not provided
Year:
2020
Organization:
UNESCO
Session:
Eighth session of the General Assembly of the States Parties
Document type:
Report / Summary
Agenda item:
11 – Update on the reflection on the listing mechanisms of the Convention
Related decisions:
13.COM 6, 13.COM 10, 14.COM 14
Meeting location:
UNESCO Headquarters, Room I
Context:
Summary of progress and reflections on the implementation and evaluation of the listing mechanisms of the 2003 Convention, including impacts of COVID-19 and planned procedural revisions.
Year:
2017
Region / City:
China
Theme:
Budget Transparency
Document Type:
Policy Note
Organization:
World Bank
Author:
Carolina Luisa Vaira, Min Zhao
Target Audience:
Governments, policy makers, researchers, international organizations
Period of validity:
Not specified
Approval Date:
Not specified
Date of Changes:
Not specified